Effect of different doses of prophylactic cranial irradiation in childhood lymphoblastic leukemia on CNS relapse, late cognitive decline and learning disabilities
نویسندگان
چکیده
Mohamed Meshref1*, Nihal ElShazly2, Mohamed Nasr3 and Rehab AbdElhai4 *Correspondence: [email protected] 1Departments of Clinical Oncology Kasr El Eini cancer centre – Faculty of Medicine Cairo University, Al-Saray street, El-Manial, Cairo 11956, Egypt. 2Department of Clinical Neurophysiology– Faculty of Medicine Cairo University, Al-Saray street, El-Manial, Cairo 11956, Egypt. 3Department of Psychiatry Faculty of Medicine Cairo University, Al-Saray street, El-Manial, Cairo 11956, Egypt. 4Department of Biostatistics and Community MedicineFaculty of Medicine Cairo University, Al-Saray street, El-Manial, Cairo 11956, Egypt.
منابع مشابه
Central nervous system relapse prophylaxis in acute lymphoblastic leukemia (ALL) intrathecal chemotherapy with and without cranial irradiation
Background: Central Nervous System (CNS) relapse in acute lymphoblastic leukemia was significantly decreased due to the use of new chemotherapyeutic agents, Intrathecal chemotherapy and cranial irradiation. The purpose of this study was to compare the effectiveness of intrathecal (IT) CNS chemotherapy alone versus combination of IT chemotherapy with cranial irradiation for prevention of CNS rel...
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The concept of CNS preventive therapy in childhood all is based on the assumption that undetectable CNS leukemia is present in most patients at the time of diagnosis, residing in that "sdnctuary site" protected by the blood-brain barrier from cytotoxic concentrations of most systemically administered antileukemic agents. Studies in the 1960s demonstrated that administration of 2400 rad cranial...
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Improved treatment for acute lymphoblastic leukemia (ALL) has virtually eliminated testicular relapse. However, the control of central nervous system (CNS) leukemia remains a therapeutic challenge in childhood ALL, partly because of the late complications arising from cranial irradiation. In most current pediatric protocols, cranial irradiation (12 to 18 Gy) is given to 5% to 25% of patients--t...
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Between 1972 and 1979, 214 children with acute lymphoblastic leukemia and no evidence of central nervous system (CNS) disease prior to CNS prophylaxis were treated with 2400 rad cranial irradiation and concurrent intrathecal methotrexate. Only nine children developed CNS leukemia; five of them in the CNS only and four concurrently in the CNS and another site. Major acute effects of CNS prophyla...
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BACKGROUND Treatment of acute lymphoblastic leukemia (ALL) has included the use of prophylactic cranial irradiation in up to 20% of children with high-risk disease despite known cognitive risks of this treatment modality. METHODS Patients enrolled on the St Jude ALL Total Therapy Study XV, which omitted prophylactic cranial irradiation in all patients, were assessed 120 weeks after completion...
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